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The opioid crisis is widely considered to have its roots in the mid-to late-1990s, when a confluence of factors—including the beginning of the “Pain as the 5th Vital Sign” campaign and the U.S. Food and Drug Administration’s approval of Purdue Pharma’s blockbuster OxyContin—led the U.S. health care system to greatly increase prescribing of opioid painkillers.
For more than a decade, the steadily increasing rate of overdose deaths involving prescription opioids continued with little notice. But that changed around 2011 when the CDC declared deaths from prescription painkillers an “epidemic.” In the years that followed, the U.S. health care and public health systems took steps to rein in prescribing of opioid painkillers. The CDC developed guidelines aimed at reducing risky prescribing patterns, and many states implemented legal restrictions in addition to the voluntary, well-meaning attempts made by many health care providers to be more cautious in prescribing opioid painkillers. The leveling-off of prescription opioid overdose deaths after 2011 suggest some degree of success, though it was limited, and rates never declined in any large or durable way.
Around the same time that prescription opioid deaths peaked, data on drug overdose deaths show that the opioid crisis made a distinct shift. Deaths began to climb first from heroin, an illegal opioid that has been trafficked for decades by criminal enterprises, then from fentanyl and similar synthetic opioids that criminal enterprises also began to traffic.
Heroin rose in popularity as individuals who were addicted to prescription opioids suddenly found themselves cut off from a substance on which they had become chemically dependent and sought out a substitute. Seeking to exploit a growing market for illicitly trafficked opioids, drug traffickers eventually turned instead to fentanyl as it is easier to produce in large quantities than heroin, has a higher potency, and is easier and cheaper to smuggle than its counterpart. Resultantly, death rates from heroin began to recede, while those from fentanyl have only continued to surge.
At the national level, data on opioid overdose deaths show multiple, evolving phases of the overdose epidemic. Pre 2011, the growth in opioid overdose deaths was driven primarily by natural and semi-synthetic opioids (i.e., prescription opioid painkillers); but that death rate has since largely plateaued.
Deaths from drug overdose have risen steadily over the past two decades and have become the leading cause of injury death in the United States. Prescription drugs, especially opioid analgesics — a class of prescription drugs such as hydrocodone, oxycodone, morphine, and methadone used to treat both acute and chronic pain — have been increasingly implicated in drug overdose deaths over the last decade. From 1999 to 2013, the rate for drug poisoning deaths involving opioid analgesics nearly quadrupled, and deaths related to heroin have also increased sharply since 2010, with a 39 percent increase between 2012 and 2013.
In response to these recent increases in opioid-related morbidity and mortality, the U.S. Department of Health and Human Services (HHS) has made addressing the opioid abuse problem a high priority and is focused on implementing evidence-based approaches to reduce: 1) opioid overdoses and overdose-related mortality and 2) the prevalence of opioid use disorder.
Symptoms and Indications of an Overdose:
What to Do:
What Not to Do:
Naloxone is a non-scheduled (non-addictive), prescription medication used in opioid overdoses to counteract life-threatening depression of the central nervous system and respiratory system, allowing an individual experiencing an overdose to breathe normally. Naloxone can be administered by non-medical personnel, which makes it ideal for individuals to treat overdose in people who have been prescribed opioid pain medication and in people who use heroin and other opioids. Naloxone only works if a person has opioids in their system and the medication has no effect if opioids are absent (National Harm Reduction Coalition). It may take multiple doses of naloxone to take effect. There is no harm in giving a person who is experiencing an overdose multiple doses of naloxone.
In the event of an overdose, complete the following steps:
STEP 1: Stimulate them awake by yelling their name and administering a hard sternum rub to the chest plate.
STEP 2: If you have naloxone/Narcan, use it. Administer one dose every two minutes.
STEP 3: Call 911; explain someone is not responsive and not breathing.
STEP 4: Provide rescue breathing. Get the person on their back, tip their head back to straighten the airway, pinch their nose, put your mouth over theirs and form a seal, one breath every five seconds.
STEP 5: When the person starts to breathe regularly on their own, roll them into a recovery position on their side.
STEP 6: Be gentle with them and yourself afterward!
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